Fluoroquinolone toxicity is the result of antibiotics that can result in extreme, whole-body effects that range that range from diarrhea, nausea, vomiting, to muscle pain as well as psychosis and depression. This is also referred to as Floxing.
Patients who have experienced adverse reactions to a fluoroquinolone/quinolone antibiotic should avoid fluoroquinolones. Aged over 65, suffering from kidney problems or who have had an organ transplant must be treated with special care.
The fluoroquinolones make up the majority of antibacterial quinolones. These antibiotics are made up of the fluorine atom, and are effective against Gram negative as well as Gram positive bacteria.
Fluoroquinolones “kill bacteria” by blocking enzymes that normally untangle DNA during cell replication. They typically cut DNA’s doublehelix, then pass another strand through the gap, and repair the damage.
However, quinolones are able to bind to enzymes and block their repair. Fluorine atoms were introduced to the quinolone structures in the 1980s. This allowed antibiotics to enter all tissues of the body and include the central nerve system. They also increased their efficacy against a wide spectrum of bacterial infections.
Fluoroquinolones can be useful in certain conditions, including life-threatening when other antibiotics aren’t to treat the problem.
But, they are also over-used just like other antibiotics. They’ve been linked with dangerous side effects throughout the years. The FDA has issued numerous warnings about their usage. Numerous changes to the label are required and certain fluoroquinolones come with warnings in black boxes.
Which antibiotics are fluoroquinolones?
These medications include Cipro (Cipro), Gemifloxacin(Factive) Levofloxacin/Levaquin Norfloxacin/Noroxin Cipro (Cipro), Cipro (Cipro), Cipro (Cipro), Cipro (Cipro), Cipro (Factive), Levofloxacin/Levaquin), Levofloxacin/Levaquin), Levofloxacin/Floxacin/Floxin (Floxin) and ofloxacin/Floxacin/Floxin (Floxin (Floxin), Cipro) gemifloxacin/Floxin (Floxin) and ofloxacin/Floxacin/Floxin (Floxin), Aveloxacin) (including ciprofloxacin).
What is the fluoroquinolone toxic syndrome?
Signs and Symptoms
Fluoroquinolone medicines have been linked to some potential serious, long-term and permanently disabling side effects, which include toxicities to the central nervous system, cardiovascular system, and musculoskeletal system. Other signs of Ciprotoxicity include:
– Mitochondrial dysfunction and DNA damage
– Brain fog
– Peripheral Neuropathy
– Blurry Vision
– DNA Damage
– Gaba and Gut damage can trigger anxiety and depression.
– Tendonitis
– Muscle Atrophy
– The increase in reflexes
The pain of low back, tendonitis and tendon rupture are among the initial signs of Ciprotoxicity. Fluoroquinolones could increase the risk of peripheral neuropathy by 47% over time.
Ciprofloxacin has been proven to alter the topology and structure of mtDNA and to block normal maintenance and transcription mitochondrial DNA. Tendinitis and tendon rupture could be caused by damaged mitochondria in tenocytes due to fluoroquinolone treatment. It may also cause inflammation and fatigue.
For more information, click fluoroquinolone toxicity treatment